
Professor Nurismah Md Isa
- Clinical Professor in Pathology
- Sir Jeffrey Cheah ºìÐÓÊÓÆµ Medical School
Biography
Current position: Consultant Pathologist ( Anatomical Pathology) at ºìÐÓÊÓÆµ Medical Centre
Previously worked in Faculty of Medicine UKM as Lecturer, Associate Professor and Consultant Pathologist
Previous responsibilities in UKM:
1. Head of Cytopathology Unit
2. Coordinators for Master of Pathology Programme, Part 1 (2009- 2013)
3. Coordinators for Master of Pathology Programme Part 2 ( 2013-2018)
3. Examiner for Master of Pathology Programme, Parts 1 and 2
4. Examiner for Master of Surgery Programme, Part 1 ( 2009-2022)
5. Editorial Board Member for Journal of Surgical Academia ( 2011-2019)
6. Member and later Chairman of Good Clinical practice Workshop committee ( 2014-2017)
7. Research Ethics Committee Member ( 2011-2017)
8. Invited as speakers for seminar, courses and conference
Academic & Professional Qualifications
- MBBCh, BAO, LRCPI & SI, Royal College of Surgeon in Ireland, Dublin Eire ( 1993)
- MPath ( Anatomical Pathology ) Universiti Kebangsaan Malaysia ( 2004)
Research Interests
- Breast and Endocrine Pathology
- Cytopathology
Teaching Areas
- Pathology(lecture/tutorial) 2003 -2006
- Personal & Profesional Development, 2007 – present
- Reproductive System(MES/Practical) , 2006 – 2023
- Urinary System(PBL/MES/Practical)2006 – 2023
- Neuroscience System(PBL/MES/Practical)2006 – 2023
- Respiratory System(PBL/MES/Practical)2006 – 2023
- Endocrine System(PBL/MES/Practical) 2006 – 2023
- Gastrointestinal System(Lecture/PBL/MES/Practical) 2006 – 2023
- Blood and Lymph(PBL/MES/Practical)2006 – 2023
- Musculoskeletal System(PBL/MES/Practical) 2006 – 2023
Notable Publications
Tan YC, Mustangin M, Rosli N, Wan Ahmad Kammal WSE, Md Isa N, Low TY, Lee PY, Chellappan DK, Jarmin R, Zuhdi Z, Azman A, Ian C, Yusof NM, Lim LC. EtOH-LN cryoembedding workflow to minimize freezing artifact in frozen tissues: A pilot study in preparing tissues compatible with mass spectrometry-based spatial proteomics application. Cryobiology. 2024 Mar;114:104843. doi: 10.1016/j.cryobiol.2023.104843. Epub 2023 Dec 27. PMID: 38158171.
Nabil S, Isa MF, Abdul Wahab BI, Isa NM. Oral mucosa sporotrichosis: Report of a rare case acquired by direct inoculation. Med Mycol Case Rep. 2024 Jan 24;43:100631. doi: 10.1016/j.mmcr.2024.100631. PMID: 38318120; PMCID: PMC10839577.
Abdullah N, Rizuana IH, Goh JHL, Lee QZ, Md Isa N, Md Pauzi SH. Bilateral metachronous breast malignancies: Malignant phylloides and invasive breast carcinoma-a case report. Front Oncol. 2023 Mar 24;13:1034556. doi: 10.3389/fonc.2023.1034556. PMID: 37035170; PMCID: PMC10080590.Mukhtar NF, Ng BK, Pauzi SHM, Wong YP, Hamizan MR, Lim PS, Isa NM. Abnormal Pap smear among pregnant women - Feasibility of opportunistic cervical screening. Eur J Obstet Gynecol Reprod Biol X. 2023 Jul 20;19:100218. doi: 10.1016/j.eurox.2023.100218. PMID: 37575365; PMCID: PMC10413414
Zin MHM , Hayati F , Suhaimi SNA , Muhammad R , Mohamad MAB , Pauzi SHM , Isa NM, Ishak MI 2023 Thyroid Collision Tumour: Concurrence of Two Thyroid Malignancy. Bangladesh Med J. 2023 Jan; 52(1) DOI:
Mohd Parid R, Wan Ahmad Kammal WSL, Jamil A, Wan Ahmad Kammal WSE, Md Isa N, Md Nor N. Remote Heparin-Induced Haemorrhagic Bullae Occurring in a Patient Treated for Acute Coronary Syndrome: A Rare Entity. Acta Cardiol Sin. 2021 Jan;37(1):111-113. doi: 10.6515/ACS.202101_37(1).20201014A. PMID: 33488036; PMCID: PMC7814329.
Wong YP, Vincent James EP, Mohammad Azhar MAA, Krishnamoorthy Y, Zainudin NA, Zamara F, Tan GC, Shah SA, Md Isa N, Baharoom A. 2021 Implementation of the International Academy of Cytology Yokohama standardized reporting for breast cytopathology: An 8-year retrospective study. Diagn Cytopathol. 2021 Jun;49(6):718-726. doi: 10.1002/dc.24731. Epub 2021 Feb 25. PMID: 33629823.
Sai Guan Lum , Nurhamizah Mahmud , Nurismah Isa , Marina Mat Baki 2020 Concurrent Double Primary Tumours: Papillary Thyroid Carcinoma and Cervical Epithelioid Angiosarcoma. Medeni Med J. 2020;35:349-55 Case Report doi:10.5222/MMJ.2020.83479
Siti Atiqah Ab Halim, Suk Kam Lee , Muaatamarulain Mustangin , Muhammad Fakhri Mohd Saleh , Shamsul Azhar Shah and Nurismah Md. Isa 2020 Expression of oestrogen-α receptor in papillary thyroid carcinoma and its association with metastasis. The Malaysian Journal of Pathology; 42(3):415-422
Wan Syahira WA Kammal, Azyani Yahaya, Shamsul A. Shah, Shahrun Niza Abdullah Suhaimi, Mazne Mahasin, MUaatamarulain Mustangin, Nurismah Md. Isa. 2019. The diagnostic utility of cytokeratin 19 in differentiating malignant from benign thyroid lesions Malaysian J Pathol 2019 ; 41(3) : 253-257
Achievements & Accolades
- CD56 Expression in Benign and Malignant Thyroid Lesions 16/06/2016-15/06/2018 Dana Fundamental PPUKM. Project Code: FF-2016-234 Principal researcher
- The Diagnostic Value of Cytokeratin-19 in Differentiating Malignant from Benign Thyroid Lesions 14/04/2016-13/04/2018 Dana Fundamental PPUKM FF-2016-126 Principal Researcher
- Prostatic Adenocarcinoma : A Review Of Clinicopathological Factors In Patient Treated With Prostatectomy With Emphasis On Gleason Pattern 4 Cancer In A Single Tertiary Institution In Kuala LumpurTanpa Biaya Project Code: FF-2015-058 Principal researcher
- Surgeon Performed Ultrasound In Indeterminate Thyroid Nodules : A Prospective Study 30/07/2015-29/07/2017 Project Code: FF-2015-278 Coresearcher
- Reliability of the Ultrasound Classification System of Thyroid Nodules in Predicting Malignancy . 30/03/2016-30/01/2018. Project Code: FF-2016-103 . Coresearcher
- Thyroid Elastography for Thyroid Nodules : A Prospective Study 20/10/2016-19/04/2018. Project Code: FF-2016-397 Co-researcher
- Diagnostic Performance Of Prostate Health Index In Detection Of Prostate Cancer . 29/01/2015-28/12/2016. Dana Fundamental PPUKM Project Code FF-2015-012. Co-researcher
- Laminin Expression In Invasive Breast Carcinoma And Its Association With Tumour Grading And Staging. 28 February 2014-27 February 2016, UKMMC Fundamental Research Fund, Project Code: FF-2014-101,Principal Researcher
- Role Of Ki-67 Labelling Index As A Prognostic Indicator In Papillary Thyroid Carcinoma : A Cross-Sectional Study. 5 January 2014-4 July 2016, UKMMC Fundamental Research Fund. Project Code: FF-2014-025, Co Researcher
- The utility of galectin-3 in differentiating benign from malignant thyroid lesions.2012- 2014, UKMMC Fundamental Research Fund, Principal Researcher
- COX-2 Overexpression in Invasive Breast Carcinoma. March 2012-February 2015, UKMMC Fundamental Research Fund. Project Code: FF-098-2012, Main Researcher/Project Head
- Development of Asian Breast Cancer Chip (ABCC) for Early-Detection and Screening of BRCA-1 and BRCA-2 mutations in Asian Population Groups, 01-01-2012-30-06-2012, Dana Inovasi UKM,Project Code:INOVASI-2011-024, Co-researcher.
- DNA Methylation for Early Detection of Cervical Cancer, 01-02-2011 - 30-09-2012, External Fund, FF-107-2011, RM112040.50. Co-researcher.
- BioPATH: A Study of Biomarker Profiles in Asia Pacific erbB2+/Her2 Breast Cancer Patients Treated with Lapatinib and Other Anti-erbB2/Her2 Therapy, 01-01-2011 - 31-07-2013,External Fund, FF-143-2011, RM 3900.00. Co-researcher.
- The prevalence and prognostic significance of lymph node micrometastasis in stages I and II colorectal cancer, January 2011-September 2012, Fundamental Research Fund, PPUKM,FF-034-2011, RM9975. Main researcher/Project Head.
- To investigate the relationship between histopathological parameters including hormone receptor status and CK14 expression in hereditary breast cancer, 01-09-2009 - 31-10-2011, Fundamental Research Fund PPUKM , FF-264-2009 , RM 5120.00. Main researcher/Project Head.
- Effects of tumeric on experimentally-induced arthritis in male rats. November 2007-April 2009, Fundamental Research Fund HUKM, FF-259-2007, RM 9910. Co-researcher.
- Correlation of E-Cadherin expression with differentiation grade and histologic type in infiltrating ductal and lobular carcinoma’,2006-2008, HUKM Research Fund, FF-071-2006, RM 5140. Main researcher/Project Head.
- Diagnosis value of body fluid cytology in detecting malignancy. 01-04-2009 - 31-05-2009,Faculty Research Fund , PPUKM, FF-018-2009 , RM 650.00. Main researcher/Project Head.
- Mutational Screening of Breast Cancer Susceptibility Genes in Families of Malaysian Patients with Breast Cancer , 01-06-2008 - 30-11-2011, Research University Grant (GUP) , UKM-GUP-TKP-08-18-065 , RM106000.00 .Co-researcher.
- Determination of HPV Genotypes in Cervical Samples of Malaysian Women , 01-06-2008 - 01-05-2011, External Fund, FF-180-2008 , RM420000.00. Co-researcher.
- Pengenalpastian Dan Pencirian Perubahan Jujukan Gen BRCA1 Di Kalangan Pesakit Kanser Payudara Berisiko Tinggi Yang Dirawat Di HUKM, HKL dan Hospital Putrajaya . 01-03-2007 - 01-03-2009
- National Biotechnology Directorate, Ministry of Science, Technology and Innovation, FF-077-2007 , RM55149.0. Main researcher/Project Head.
- Pengenalpastian dan Pencirian Jujukan Pada Gen BRCA2 di Kalangan Pesakit Kanser Payudara Berisiko Tinggi di HUKM, HKL dan HPJ ,01-03-2007 - 01-03-2009,National Biotechnology Directorate, Ministry of Science, Technology and Innovation FF-092-2007 , RM68942.00. Main researcher/Project Head
- Pengesanan Mutasi pada Gen-gen BRCA1 dan BRCA2 di Kalangan Pesakit Kanser Payudara Berisiko Tinggi di HUKM, HKL dan Hospital Putrajaya dengan Menggunakan Kaedah DHPLC dan MLPA 01-03-2007 - 01-03-2009, National Biotechnology Directorate, Ministry of Science, Technology and Innovation FF-078-2007, RM40848.00. Main researcher/Project Head
- The Clinical Value Of Human Mamaglobin (Hmam) In Breast Cancer 01-12-2006 - 30-11-2008, Sciencefund , 02-01-02-SF0122 , FF-75-2004, RM150000.00. Co-researcher
- Identification and characterisation of factors that underlie breast cancer development in Malaysian patients.01-11-2004 - 30-11-2007,National Biotechnology Directorate, Ministry of Science, Technology and Innovation,09-02-02-009 BTK/ER/37/1 , RM361836.00.Main researcher/Project Head
- Molecular analysis of H-ras oncogene mutation at codon 12 in follicular neoplasms of the thyroid. 2000-2002,Faculty Research Fund RM5000.Co-researcher
Professional Associations
1. International Academy of Pathology ( Malaysia Division)
2. College of Pathologist, Academy of Medicine, Malaysia ( AM, Mal)
3. Member of International Academy of Cytology ( MIAC)
4. Malaysian Society of Cytology 2024