Professor Low Teck Yew

Professor Low Teck Yew

  • Head of Centre
  • Professor
  • Sir Jeffrey Cheah 红杏视频 Medical School
Faculty of Medical and Life Sciences
SDGs Focus

Biography

Professor Low Teck Yew brings over two decades of research experience in proteomics, biological mass spectrometry, and proteogenomics. He is internationally recognized for his high-impact publications, invited talks at global conferences, and leadership roles in prominent scientific organizations. Through active involvement in interdisciplinary projects and a strong international network, he contributes significantly to global proteomics initiatives. Beyond his research, Professor Low is a passionate mentor and educator who fosters critical thinking and intellectual curiosity through innovative teaching methods. His leadership in AOHUPO and HUPO plays a key role in identifying and nurturing the next generation of international research talent.

Academic & Professional Qualifications

  • PhD, National University of Singapore, Singapore (2005)
  • BSc (Hons) ARCS,Imperial College of Science, Technology and Medicine, London (1998)

Research Interests

  • Multi-omics
  • Proteomics
  • Biological mass spectrometry
  • Proteogenomics
  • Non-canonical proteins

Teaching Areas

  • Biochemistry
  • Omics
  • Molecular Medicine

Courses Taught

  • IO1214 & BIO2024: Basic Biochemistry
  • BIO2214: Medical Biochemistry
  • BIO3024: Current Topics in Biomedical Sciences

Notable Publications

  1. He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizca铆no JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q, Zhu Y; 蟺-HuB Consortium. 蟺-HuB: the proteomic navigator of the human body. Nature. 2024 Dec;636(8042):322-331. doi: . Epub 2024 Dec 11. Erratum in: Nature. 2025 Jan;637(8046):E22Tan YC, Low TY, Lee PY, Lim LC. Single-cell proteomics by mass spectrometry: Advances and implications in cancer research. Proteomics. 2024 Jun;24(12-13):e2300210.
  2. Mohamad Zamberi NN, Abuhamad AY, Low TY, Mohtar MA, Syafruddin SE. dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer. CRISPR J. 2024 Apr;7(2):73-87.
  3. Tan YC, Mustangin M, Rosli N, Wan Ahmad Kammal WSE, Md Isa N, Low TY, Lee PY, Chellappan DK, Jarmin R, Zuhdi Z, Azman A, Ian C, Yusof NM, Lim LC. EtOH-LN cryoembedding workflow to minimize freezing artifact in frozen tissues: A pilot study in preparing tissues compatible with mass spectrometry-based spatial proteomics application. Cryobiology . 2024 Mar;114:104843.
  4. Lee PY, Md Azhan FS, Low TY. Biomarkers for colorectal cancer chemotherapy: Recent updates and future perspective. Malays J Pathol . 2023 Dec;45(3):317-331.
  5. Colozza G, Lee H, Merenda A, Wu SS, Catal脿-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, Low TY, Maurice MM, Bryja V, Kim J, Koo BK. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Sci Adv . 2023 Nov 24;9(47):eadh9673.
  6. Low TY. Elucidating the dynamic remodelling of Escherichia coli interactome in different growth conditions using multiplex co-fractionation MS (mCF-MS). Proteomics. 2023 Nov;23(21-22):e2300209.
  7. Hatta MNA, Mohamad Hanif EA, Chin SF, Low TY, Neoh HM. Parvimonas micra Infection Enhances Proliferation, Wound Healing, and Inflammation of a Colorectal Cancer Cell Line. Biosci Rep. 2023 May 23:BSR20230609. doi: Epub ahead of print.
  8. Kovanich D, Low TY, Zaccolo M. Using the Proteomics Toolbox to Resolve Topology and Dynamics of Compartmentalized cAMP Signaling. Int J Mol Sci. 2023 Feb 28;24(5):4667.
  9. Low TY, Chen YJ, Ishihama Y, Chung MCM, Cordwell S, Poon TCW, Kwon HJ. The Second Asia-Oceania Human Proteome Organization (AOHUPO) Online Education Series on the Renaissance of Clinical Proteomics: Biomarkers, Imaging and Therapeutics. Mol Cell Proteomics. 2022 Dec;21(12):100436.
  10. Leong AZ, Lee PY, Mohtar MA, Syafruddin SE, Pung YF, Low TY. Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures. J Biomed Sci. 2022 Mar 17;29(1):19. doi: .
     

Achievements & Accolades

  1. World Top 2% Scientists - by Elsevier and Stanford University in the main field of Biomedical Research, the sub-field of Biochemistry and Molecular Biology [2024].
  2. Top Downloaded Article 2022 鈥 The FEBS Journal (WILEY) 鈥 鈥 A recent update on small-molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry-based proteomic analysis 鈥 - Among work published in an issue between 1 January 2022 鈥 31 December 2022.
  3. Top Cited Article 2021-2022 鈥 Mass Spectrometry Reviews (WILEY) 鈥 鈥 Widening the Bottleneck of Phosphoproteomics: Evolving Strategies for Phosphopeptide Enrichment 鈥 - Among work published in an issue between 1 January 2021 鈥 15 December 2022.
  4. Editor-in-Chief for Proteome Science, a BMC journal (Springer-Nature)
  5. Editorial Board Member for Molecular & Cellular Proteomics (ASBMB & Elsevier)
  6. External Advisory Board Member - the Institute of Medical Molecular Biotechnology (IMMB), Universiti Teknologi Mara (UiTM), Malaysia (2021-2024)
  7. Project Progress Monitoring and Review Committee Member (PPMRC) - the Sarawak Research and Development Council (SRDC) grant schemes (2021-)
  8. External Fellow - the Centre for Cancer and Stem Cell Research, International Medical University (IMU) Institute for Research, Development, and Innovation (IRDI), Malaysia (2020-2023)
  9. Scientific Advisor - Belt and Road Initiative (BRI) Foreign Expert Program, Westlake University, Hangzhou, China锛2022-锛
  10. Founding Council - 蟺-HuB Consortium: The Proteomic Navigator of The Human Body (2023-)
  11. Co-chair - The Joint 11th AOHUPO (Asia Oceania Human Proteome Organization) & 7th AOAPO (Asia Oceania Agricultural Proteomics Organization) Congress in conjunction with SSMS (Singapore Society of Mass Spectrometry) 2023 鈥 5th-8th May 2023 EXPO Singapore
  12. Chair - Organizing Committee for the 2nd AOHUPO Online Educational Series - The Renaissance of Clinical Proteomics: Biomarkers, Imaging and Therapeutics - 11th 鈥 25th March 2022

Professional Associations

  1. Elected Council Member, Human Proteome Organization (HUPO)
  2. Secretary-General, Asia Oceania Human Proteome Organization (AOHUPO)
  3. President, Malaysia Proteomics Society (MAPS)
  4. Member, American Society of Biochemistry and Molecular Biology (ASBMB)
  5. Member, Malaysia Society of Biochemistry and Molecular Biology (MSBMB)
  6. Member, American Society of Mass Spectrometry (ASMS)