Dr Sharifah Nadhira Syed Annuar

Dr Sharifah Nadhira Syed Annuar

  • Post Doctoral Research Fellow
Department of Clinical Medicine and Surgery
  • Faculty of Medical and Life Sciences
Faculty of Medical and Life Sciences
SDGs Focus

Biography

Dr Sharifah Nadhira Binti Syed Annuar earned her PhD in Toxicology from Universiti Kebangsaan Malaysia (UKM) in 2023, with her dissertation focusing on the molecular mechanisms of cytotoxicity induced by organotin(IV) dithiocarbamate compounds in human leukemia cell lines (K562 and Jurkat E6.1). Her work contributes to the understanding of anticancer metallodrugs and their potential therapeutic applications. She is committed to advancing research in toxicology and cancer therapeutics.

Academic & Professional Qualifications

  • Bachelor of Environmental Health, Universiti Kebangsaan Malaysia (2019)
  • Phd (Toxicology), Universiti Kebangsaan Malaysia (2023)

Research Interests

  • Mechanistic Toxicology
  • Cancer Research
  • Drug Development

Notable Publications

  1. Sharifah Nadhira Syed Annuar, Nurul Farahana Kamaludin, Normah Awang & Kok Meng Chan. 2021. Cellular basis of organotin(IV) derivatives as anticancer metallodrugs: a review. Frontiers in Chemistry 9: 1-15. (Q2, Impact Factor = 5.545, WOS/SCOPUS-Cited Publication)
  2. Sharifah Nadhira Syed Annuar, Nurul Farahana Kamaludin, Normah Awang & Kok Meng Chan. 2022. Triphenyltin(IV) dithiocarbamate compound induces genotoxicity and cytotoxicity in K562 human erythroleukemia cells primarily via mitochondria-mediated apoptosis. Food and Chemical Toxicology 168: 113336-113348. (Q1, Impact Factor = 5.572, WOS/SCOPUS-Cited Publication.
  3. Sharifah Nadhira Syed Annuar, Nurul Farahana Kamaludin, Normah Awang & Kok Meng Chan. 2023. Diorganotin(IV) N-methyl-N-phenethyldithiocarbamate compounds induce cytotoxicity via apoptosis in K562 human erythroleukaemia cells. Sains Malaysiana 52(5): 1513-1521. (Q4, Impact Factor = 0.8, WOS/SCOPUS-Cited Publication)
  4. Normah Awang, Nur Hidayah Hasrin, Nurul Farahana Kamaludin, Sharifah Nadhira Syed Annuar, Nur Rasyiqin Rasli & Asmah Hamid. 2023. Use of novel triphenyltin(IV) dithiocarbamate compounds in assessing the cytotoxicity and mode of cell death of acute lymphoblastic leukemia cells lines, CCRF CEM (CCL-119). OnLine Journal of Biological Sciences 23(2): 142-148. (SCOPUS-Cited Publication)
  5. Normah Awang, Noor Hanim Mohd Nor, Nurul Farahana Kamaludin & Sharifah Nadhira Syed Annuar. 2023. Triphenyltin(IV) dithiocarbamate compounds induce cytotoxicity in acute lymphoblastic leukemia (Jurkat E6.1) primarily via DNA fragmentation and cell cycle arrest. Journal of Medicinal and Chemical Sciences 6: 2397-2406. (SCOPUS-Cited Publication)
  6. Nurul Farahana Kamaludin, Sharifah Nadhira Syed Annuar & Normah Awang. 2021. Penilaian sitotoksisiti dan mod kematian sel aruhan sebatian diorganostanum(IV) ditiokarbamat terhadap sel eritroleukemia manusia, K562. In Awang, N. & Kamaludin, N.F. (ed), Potensi antileukemia sebatian organostanum(IV) ditiokarbamat, pg. 18-36. UKM Publisher, Universiti Kebangsaan Malaysia, Bangi.