Dr Tan Ee Wern

Dr Tan Ee Wern

  • Post Doctoral Research Fellow
红杏视频 Biofunctional Molecules Discovery Centre
  • Faculty of Medical and Life Sciences
Faculty of Medical and Life Sciences
SDGs Focus

Biography

Dr Tan Ee Wern obtained her PhD in Biology from 红杏视频 University in 2024. Her research expertise lies in drug discovery, molecular oncology and cancer biology, with a strong interest in developing targeted therapeutic strategies for chemo-resistant cancers. Her current research focuses on the use of adenoviral vectors to drive tumour suppressor gene expression, aiming to improve the efficacy of combination cancer treatments.  

Academic & Professional Qualifications

  • PhD in Biology, 红杏视频 University, Malaysia (2024)
  • MSc (Applied Sciences by Research), UCSI University, Malaysia (2019)
  • BSc (Hons) Biotechnology, UCSI University, Malaysia (2016)

Research Interests

  • Drug discovery
  • Molecular Oncology
  • Cancer Biology

Notable Publications

  1. Ee Wern Tan, Ley Hian Low, Atanas G. Atanasov and Bey Hing Goh (2025).  Bridging Traditions and Technology: The Role of Ethnopharmacology in Shaping Next鈥怗eneration Multidisciplinary Researchers.  Pharmacology Research & Perspectives,  13(1):e70074. DOI: 10.1002/prp2.70074
  2. Ee Wern Tan, Kuan Onn Tan, and Bey Hing Goh (2024).  AdenoCure 3X: Establishing a Sensitized Cancer Cell Model to Accelerate Novel Drug Discovery.  Progress in Drug Discovery & Biomedical Science, 7 (1).  DOI: 10.36877/pddbs.a0000530
  3. Ee Wern Tan, Amar Daud Iskandar Abdullah, Long Chiau Ming, Chit Laa Poh, Bey Hing Goh, Tze Pheng Lau, and Kuan Onn Tan (2024). Adenovirus-mediated expression of MOAP-1, Bax and RASSF1A antagonizes chemo-drug resistance of human breast cancer cells expressing cancer stem cell markers. Biomedicine & Pharmacotherapy, 176, 116744. DOI: 10.1016/j.biopha.2024.116744
  4. Ee Wern Tan, Samson Eugin Simon, Arshid Numan, Mohammad Khalid, Kuan Onn Tan (2024). Impact of UV Radiation on Mxene-Mediated Tubulin Dissociation and Mitochondrial Apoptosis in Breast Cancer Cells. Colloids and Surfaces B: Biointerfaces, DOI: 10.1016/j.colsurfb.2024.113793
  5. Ee Wern Tan, Noraini Abd-Aziz, Chit Laa Poh and Kuan Onn Tan (2022). Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy. Pathogens, 11, 1146.
  6. Samson Eugin Simon, Usman Ahmed, Syed Muhammad Saad, Ayaz Anwar Khalid Mohammed Khan, Ee Wern Tan, and Kuan Onn Tan (2022). New synthetic phenylquinazoline derivatives induce apoptosis by targeting the pro-survival members of the BCL-2 family. Bioorganic & Medicinal Chemistry Letters, 67, pg. 128731. DOI: 10.1016/j.bmcl.2022.128731
  7. Samson Eugin Simon, Hui Sin Lim, Fairen Angelin Jayakumar, Ee Wern Tan and Kuan Onn Tan (2021). Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine, Article ID 7548191. DOI:10.1155/2022/7548191
  8. Winfrey Pui Yee Hoo, Pui Yan Siak, Nur Aqlili Riana Alias, Jia Jia Wong, Ee Wern Tan, Adelene Ai-Lian Song, Raha Abdul Rahim, and Lionel Lian Aun In (2019). K-ras peptide mimotope induces a humoral 1 immune response against G12V K-ras antigen in BALB/c mice. Asia Pacific Journal of Molecular Biology and Biotechnology. 28 (3), pg 22-35. DOI: 10.35118/apjmbb.2020.028.3.03
  9. Ee Wern Tan, Kean Yuen Tan, Li Voon Phang, P. V. Kumar, and Lionel L. A. In. (2018). Enhanced gastrointestinal survivability of recombinant Lactococcus lactis expressing KRAS peptide vaccine using a double coated mucoadhesive film approach. PLoS ONE. 14 (7): e0219912. DOI:10.1371/journal.pone.0219912

  10. Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song and Lionel L.A. In. (2017). In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens. PeerJ. 6:e5056 https://doi.org/10.7717/peerj.5056


     

Achievements & Accolades

  1. The Ad-MBRG Model: A High-Throughput Screening Platform for Synergistic Cancer Therapeutics Discovery
  2. Adenovirus-Mediated Tumour Suppressor Gene Expression (Ad-MBRG): A Sensitized Human Cancer Model to Augment the Efficacy of Compounds in Advancing Therapeutic Intervention